Loyola (Chicago) beating Cincinnati in the 1963 National Championship game is considered one of the greatest upsets in NCAA Tournament history. At the beginning of the tournament, Loyola was a 100-1 shot. Loyola came from 15 points behind to win - keeping Cincinnati from winning a third consecutive national title.

One note: As prologue to what was to happen in 1966, Loyola was the first team to start four black players.