A 16 seed has never beaten a 1 seed in the NCAA tournament. But this game is the second closest it has ever come. At one point in the 2nd half, Albany led by 12 points. At that point, UConn came to their senses, and the world returned to normal.
The closest a 16 came to beating a 1 seed was the 1990 Southeast regional, where #1 Michigan State had to go overtime to beat #16 Murray State 75-71.